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Axin-2 polyclonal antibody

CAT: 0384-BS67312-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS67312-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Axin1 (Axis inhibition protein 1) and Axin2 are multidomain scaffold proteins that negatively regulate Wnt signaling. Axin1 interacts with APC, GSK-3β, Dvl, and β-catenin and promotes the GSK-3β-mediated phosphorylation and subsequent degradation of β-catenin . Upon stimulation of cells with Wnt, Axin1 is recruited to the membrane by phosphorylated LRP5/6, a process that is believed to be crucial for activation of Wnt signaling . In addition to its role in the Wnt signaling pathway, Axin1 forms a complex with MEKK1 and activates c-Jun amino-terminal kinase (JNK/SAPK) . Axin2 (also known as Conductin or Axil) can functionally substitute for Axin1 in mice . Axin2 itself is a direct target of the Wnt signaling pathway and therefore serves to control the duration and/or intensity of Wnt signaling through a negative feedback loop .
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
Axin-2; Axin-like protein; Axil; Axis inhibition protein 2; Conductin
Swiss Prot
Q9Y2T1
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant full length protein of human Axin-2
Conjugation
Unconjugated
Related Pathways
ESC Pluripotency and Differentiation Signaling Pathway, Wntβ catenin signaling
Applications
WB, IF/ICC
Dilution
WB (1/500 - 1/2000), IF/ICC (1/50 - 1/200)
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 91 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of Axin-2 protein.
Applications Notes
Western blot analysis of Axin-2 expression in mouse lung (A), mouse brain (B), mouse liver (C) whole cell lysates.
Host or Source
Rabbit

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