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IDE monoclonal antibody

CAT: 0384-MB65959-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-MB65959-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Insulin degrading enzyme (IDE), initiates the cleavage of Insulin, resulting in Insulin response and resistance. However, IDE also degrades a variety of bioactive peptides, including Amyloid-β peptides, implicating IDE in certain age-related changes seen in Alzheimer’s disease. Studies show that when the expression of the IDE gene (chromosome 10q23.33) is altered, changes occur not only in glucose homeostasis, but also in the levels of brain Aβ40 and Aβ42 peptides. An IDE inhibitor, bacitracin, inhibits degradation of both Insulin and amylin, indicating that both are degraded through a common proteolytic pathway. Variations in the rate of proteolysis suggest that the function of IDE exhibits conformational dependence, which may lead to possible therapeutic interventions for diabetes, AD, and other diseases associated with IDE substrate proteolysis.
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
Insulin-degrading enzyme; Abeta-degrading protease; Insulin protease; Insulinase; Insulysin
Swiss Prot
P14735
Reactivity
Human
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence of human IDE. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/1000 - 1/2000)
Purity
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 118 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of IDE protein.
Applications Notes
Western blot analysis of IDE expression in Hela (A), HepG2 (B) whole cell lysates.
Host or Source
Mouse

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