Products for Research Use Only
RegisterLogin

CD28 monoclonal antibody

CAT: 0384-MB65816-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0384-MB65816-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
CD28 is a transmembrane glycoprotein expressed by T cells as well as some other hematopoietic cells. T cell activation requires T cell receptor (TCR) recognition of antigen presented in the context of MHC molecules. CD28 acts as a T cell costimulatory receptor, and interaction of CD28 with its ligands CD80 or CD86 provides the second signal required for naïve T cell activation . Activation of naïve T cells in the absence of CD28 stimulation can result in a state of T cell anergy, or unresponsiveness . CD28 signals through cytoplasmic phospho-tyrosine motifs that bind several SH2 or SH3 domain-containing proteins involved in T cell activation. Recently, CD28 was demonstrated to be a preferred target of PD-1-mediated dephosphorylation. Consistently, CD28 expression was required for T cell proliferation following PD-1 blockade and CD28 stimulation was required for effective anti-PD-1 cancer immunotherapy in mice. Several CD28 isoforms are produced by alternative splicing.
CAS Number
9007-83-4
Structure Composition
Mouse IgG1 kappa. Liquid in PBS, pH 7.3, and 0.02% sodium azide.
Product Name Alternative
T-cell-specific surface glycoprotein CD28; TP44; CD28
Swiss Prot
P10747
Reactivity
Human
Immunogen
Native purified human CD28
Conjugation
Unconjugated
Applications
IF, FC
Dilution
IF (1/50 - 1/200)
Purity
The monoclonal antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 25 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes human CD28
Host or Source
Mouse

Related Products

CatalogName
EP0028Human CD28 (3G5E) monoclonal antibody
MB65833-01CD28 Syrian Hamster monoclonal antibody
BS77260-01CD28 polyclonal antibody
BS65740-01CD28 Polyclonal Antibody
BS48458-01CD28 Recombinant Rabbit mAb
BS49093-01CD28 Recombinant Rabbit mAb
BS49038-01CD28 Recombinant Rabbit mAb
MB65766-01CD23 monoclonal antibody
MB65989CD21 monoclonal antibody
MB10688CD27 monoclonal antibody

Alternative Products

CatalogName
BT-MCA4328-01CD28 Monoclonal Antibody
NBP1-79126Mouse Monoclonal CD28 Antibody (CD28.2)
AMM00025GMonoclonal CD28 FITC Monoclonal Antibody (Clone CD28.2), Clone: CD28.2
NBP1-79126PEMouse Monoclonal CD28 Antibody (CD28.2) [PE]
30-1401-0.1Anti-CD28 Monoclonal Antibody (Clone:CD28.2)
NBP1-79126APCMouse Monoclonal CD28 Antibody (CD28.2) [Allophycocyanin]
NBP1-79126BMouse Monoclonal CD28 Antibody (CD28.2) [Biotin]
6957-25CD28 FITC Monoclonal Antibody (Clone CD28.2)
NBP1-79126PCPMouse Monoclonal CD28 Antibody (CD28.2) [PerCP]
NBP1-79126HMouse Monoclonal CD28 Antibody (CD28.2) [HRP]

Popular Products