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CD56 monoclonal antibody

CAT: 0384-MB65795-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-MB65795-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NCAM (neural cell adhesion molecule, CD56) is an adhesion glycoprotein with five extracellular immunoglobulin-like domains followed by two fibronectin type III repeats. Structural diversity is introduced by alternative splicing resulting in different cytoplasmic domains. NCAM mediates neuronal attachment, neurite extension, and cell-cell interactions through homo and heterophilic interactions. PSA (polysialic acid) post-translationally modifies NCAM and increases the metastatic potential of small cell lung carcinoma, Wilms+ tumor, neuroblastoma, and rhabdomyosarcoma. CD56 is commonly used along with CD3 and CD16 to identify human NK cells (Mouse NK cells do not express CD56) . Human natural killer cells are CD3-CD56+. The large subset with high CD16 expression are mature cytotoxic natural killer cells, while those with low CD16 expression are immature precursors and cytokine producers.
CAS Number
9007-83-4
Structure Composition
Mouse IgG2a kappa. Liquid in PBS, pH 7.3, 0.2% BSA, and 0.02% sodium azide.
Product Name Alternative
NCAM; Neural cell adhesion molecule 1; N-CAM-1; NCAM-1; CD antigen CD56
Swiss Prot
P13591
Reactivity
Human
Immunogen
Native purified human CD56.
Conjugation
Unconjugated
Applications
IF, FC
Dilution
IF (1/50 - 1/200)
Purity
The monoclonal antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 94 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes human CD56
Applications Notes
Flow cytometric analysis of human peripheral blood lymphocytes using Anti-CD56 Antibody, followed by anti-mouse IgG PE.
Host or Source
Mouse

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