ABHD12 polyclonal antibody

CAT: 0384-BS67231-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS67231-01Size:50 µL
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Background
Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (PubMed:25290914, PubMed:30237167, PubMed:30420694, PubMed:30720278, PubMed:30643283) . Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity) . Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal (PubMed:30643283) . Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways (PubMed:22969151, PubMed:24027063) . Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (PubMed:30237167) .
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
C20orf22; Monoacylglycerol lipase ABHD12; 2-arachidonoylglycerol hydrolase; Abhydrolase domain-containing protein 12
Swiss Prot
Q8N2K0
Reactivity
Human
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human ABHD12. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB, IHC
Dilution
WB (1/500 - 1/1000), IHC (1/50 - 1/200)
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 192% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 45 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of ABHD12 protein.
Applications Notes
Western blot analysis of ABHD12 expression in A549 (A), HepG2 (B) whole cell lysates.
Host or Source
Rabbit

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