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B-RAF (phospho-S446) polyclonal antibody

CAT: 0384-BS67111-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS67111-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable) . Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126) .May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179) .
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
BRAF1; RAFB1; Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1
Swiss Prot
P15056
Reactivity
Human, Mouse, Rat
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human B-RAF. The exact sequence is proprietary.
Conjugation
Unconjugated
Related Pathways
MAPK Erk in Growth and Differentiation Pathway
Applications
WB, IHC
Dilution
WB (1/500 - 1/1000), IH (1/100 - 1/200)
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Phosphorylation
Molecular Weight
~ 93 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of B-RAF (pS446) protein.
Applications Notes
Western blot analysis of B-RAF (pS446) expression in HEK293T (A), mouse brain (B), rat brain (C) whole cell lysates.
Host or Source
Rabbit

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