CD66a/e polyclonal antibody

• Background :

  Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity) .Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis (PubMed:18424730, PubMed:23696226, PubMed:25363763) .Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils (PubMed:18424730, PubMed:23696226) .

• Structure Composition :

  Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

• Product Name Alternative :

  CEACAM1; BGP; BGP1; Carcinoembryonic antigen-related cell adhesion molecule 1; Biliary glycoprotein 1; BGP-1; CD66a; CEACAM5; CEA; Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen; CEA; Meconium antigen 100; CD66e

• Swiss Prot :

  P13688; P06731

• Reactivity :

  Human

• Immunogen :

  KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CD66a/e. The exact sequence is proprietary.

• Conjugation :

  Unconjugated

• Applications :

  WB

• Dilution :

  WB (1/500 - 1/1000)

• Purity :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification :

  Unmodification

• Molecular Weight :

  ~ 180 kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  Recognizes endogenous levels of CD66a/e protein.

• Applications Notes :

  Western blot analysis of CD66a/e expression in HUT78 (A), HCT116 (B) whole cell lysates.

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4