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TEC (Q75) polyclonal antibody

CAT: 0384-AP0820-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-AP0820-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Tec kinase belongs to a structurally related subfamily of protein tyrosine kinases (PTKs) that includes Btk, Itk (also known as Emt or Tsk), Bmx, and Txk (or Rlk) . With the exception of Txk, the members of this subfamily possess a long amino-terminal region consisting of a pleckstrin homology (PH) domain and a Tec homology (TH) domain . Because PH domains bind phosphoinositides with high affinity, the Tec family kinases have been proposed to act downstream of phosphatidylinositol 3-kinase (PI3-kinase) in signaling pathways. Binding of the PH domain with phosphoinositides is probably required for targeting of Tec family kinases to the cell membrane. Tec kinase is activated in response to many upstream signaling events including antigen receptor, RTK, GPCR, and integrin stimulation. Activated Tec kinase directly phosphorylates substrates such as PLC-gamma 2 and BRDG1 docking protein and mediates downstream signaling.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
Tyrosine-protein kinase Tec; TEC; PSCTK4
Swiss Prot
P42680
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide, corresponding to Human TEC.
Conjugation
Unconjugated
Applications
WB IF
Dilution
WB: 1:1000~1:2000 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 70 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
TEC (Q75) polyclonal antibody detects endogenous levels of TEC protein.
Applications Notes
Western blot (WB) analysis of TEC (Q75) polyclonal antibody at 1:2000 dilution Lane1:Hela whole cell lysate (40ug) Lane2:MCF-7 whole cell lysate (40ug) Lane3:CT-26 whole cell lysate (40ug) Lane4:PC12 whole cell lysate (40ug)
Host or Source
Rabbit

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