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CCAR1 polyclonal antibody

CAT: 0384-BS8140-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS8140-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CARP-1 (cell division cycle and apoptosis regulator 1), also known as CCAR1 or DIS, is a 1,150 amino acid protein that localizes to the perinuclear region of the cytoplasm and contains one SAP domain. Expressed in several epithelial cancer cell lines, including breast, colon, prostate and leukemia, CARP-1 is involved in apoptotic signaling, as well as in cell cycle progression and cell proliferation via interaction with c-Myc and cyclin B1. CARP-1 is subject to DNA damage-induced phosphorylation, probably by ATM or ATR. The gene encoding CARP-1 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.
CAS Number
9007-83-4
Structure Composition
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Product Name Alternative
Cell division cycle and apoptosis regulator protein 1; Cell cycle and apoptosis regulatory protein 1; CARP-1; Death inducer with SAP domain; CCAR1; CARP1; DIS
Swiss Prot
Q8IX12
Reactivity
Human, Mouse, Rat
Immunogen
KLH conjugated synthetic peptide derived from human DIS/CCAR1: 731-830/1150
Conjugation
Unconjugated
Applications
ELISA IHC IF
Dilution
IHC: 1:100~1:500 IF: 1:100~1:500 ELISA: 1:5000~1:10000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 133 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CCAR1 polyclonal antibody detects endogenous levels of CCAR1 protein.
Host or Source
Rabbit

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