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UCP1 polyclonal antibody

CAT: 0384-BS70689-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS70689-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Uncoupling protein 1 (UCP1) is a mitochondrial inner membrane transport protein that is primarily expressed in brown adipose tissue (BAT) . UCP1 dissipates the pH gradient resulting from oxidative phosphorylation, which uncouples ATP synthesis from oxidative phosphorylation and leads to the release of heat energy. As a result, UCP1 plays an important role in thermogenesis. Research studies indicate that subcutaneous white adipose depots in mice contain beige adipocytes that express low levels of UCP1 protein. Additional studies show possible differences in thermogenesis in individuals carrying specific polymorphisms in the corresponding UCP1 gene. Related studies link UCP1 to the possible development of obesity and type 2 diabetes.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
UCP1; SLC25A7; UCP
Swiss Prot
P25874
Reactivity
Mouse, Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human UCP1 (NP_068605.1) .
Conjugation
Unconjugated
Applications
WB IHC IF
Dilution
WB: 1:500~1:2000 IHC: 1:50~1:200 IF: 1:50~1:100
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 30 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
UCP1 polyclonal antibody detects endogenous levels of UCP1 protein.
Applications Notes
Western blot analysis of extracts of various cell lines, using UCP1 antibody at 1:710 dilution.
Host or Source
Rabbit

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