LSM4 polyclonal antibody

• Background:

  Sm and Sm-like (LSm) proteins form donut shaped heptameric complexes that are involved in various steps of RNA metabolism. Lsm proteins facilitate RNA protein interactions and structural changes that are required during ribosomal subunit assembly. LSm4, also called U6 snRNA-associated Sm-like protein or Glycine-rich protein (GRP), binds specifically to the 3'-terminal U-tract of U6 snRNA. Human LSm4 localizes to the cytoplasm in small, discrete foci. These foci are also the localization site for the mRNA decapping enzyme Dcp1/2 and the exonuclease, Xm1.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  U6 snRNA-associated Sm-like protein LSm4; Glycine-rich protein; GRP; LSM4

• Swiss Prot:

  Q9Y4Z0

• Reactivity:

  Human, Mouse

• Immunogen:

  Synthetic peptide, corresponding to Human LSM4.

• Conjugation:

  Unconjugated

• Applications:

  WB

• Dilution:

  WB 1:500 - 1:1000

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  ~ 15 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  LSM4 polyclonal antibody detects endogenous levels of LSM4 protein.

• Applications Notes:

  Western blot analysis of LSm4 expression in K562 (A), NIH3T3 (B) whole cell lysates.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4