IL-23 alpha polyclonal antibody

• Background:

  Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells.

• Structure Composition:

  Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

• Product Name Alternative:

  SGRF; Interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; Interleukin-23 subunit p19; IL-23p19

• Swiss Prot:

  Q9NPF7

• Reactivity:

  Human, Mouse

• Immunogen:

  KLH-conjugated synthetic peptide encompassing a sequence within the center region of human IL-23 alpha. The exact sequence is proprietary.

• Conjugation:

  Unconjugated

• Applications:

  WB, FC

• Dilution:

  WB (1/500 - 1/1000), FC (1/10 - 1/50)

• Purity:

  The antibody was purified by immunogen affinity chromatography.

• Modification:

  Unmodification

• Molecular Weight:

  ~ 20 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  Recognizes endogenous levels of IL-23 alpha protein.

• Applications Notes:

  Western blot analysis of IL-23 alpha expression in mouse pancreas (A) whole cell lysates.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4