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MO25 monoclonal antibody

CAT: 0384-MB67258-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-MB67258-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
AMPK (AMP-activated protein kinase) is a key cellular component that regulates energy homeostasis. When the AMP/ATP ratio is increased due to energy depletion, AMPK is phosphorylated at its α1 and α2 catalytic subunits and activated. Studies showed that the tumor suppressor LKB1 phosphorylates and activates AMPK in mammals. MO25α (mouse protein 25α), also called CAB39 (calcium binding protein 39), is a component of the LKB1 complex in vivo. MO25α/CAB39 does not directly interact with LKB1; instead, it is physically associated with STRADα. Together MO25α/CAB39 and STRADα help anchor LKB1 in the cytoplasm. MO25α/CAB39 stablizes the LKB1-STRADα complex and further increases the catalytic activity of LKB1.
CAS Number
9007-83-4
Structure Composition
Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
MO25; Calcium-binding protein 39; MO25alpha; Protein Mo25
Swiss Prot
Q9Y376
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human MO25. The exact sequence is proprietary.
Conjugation
Unconjugated
Related Pathways
AMPK Signaling Pathway
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 35 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of MO25 protein.
Applications Notes
Western blot analysis of MO25 expression in K562 (A), mouse brain (B) whole cell lysates.
Host or Source
Mouse

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