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HAS2 monoclonal antibody

CAT: 0384-MB67169-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-MB67169-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HAS1, HAS2 and HAS3 are HA synthase proteins that synthesize HA (hyaluro_x0002_nan or hyaluronic acid) . The extracellular matrix in most vertebrates expres HA, which is a high molecular weight linear polysaccharide composed of alter_x0002_nating glucuronic acid and N-acetylglucosamine residues linked by β-1,3 andβ-1,4 glycosidic bonds. The three HAS genes show distinct patterns of expres_x0002_sion during development and their protein products play significantly different roles in the formation of the HA matrix. Both HAS1 and HAS2 synthesise high molecular-weight HA, whereas HAS3 produces lower molecular weight HA. The expression of the three HAS isoforms is more prominent in growing cells than in resting cells and is differentially regulated by various stimuli suggest_x0002_ing distinct functional roles of the three proteins. HAS2 mRNA shows pre_x0002_dominant expression in chondrocytes and cartilage. The human HAS2 gene maps to chromosome 8q24.13
CAS Number
9007-83-4
Structure Composition
Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
Hyaluronan synthase 2; Hyaluronate synthase 2; Hyaluronic acid synthase 2; HA synthase 2
Swiss Prot
Q92819
Reactivity
Human
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human HAS2. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/4000)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 68 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of HAS2 protein.
Applications Notes
Western blot analysis of HAS2 expression in SW620 (A) whole cell lysates.
Host or Source
Mouse

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