Products for Research Use Only
RegisterLogin

RNF4 monoclonal antibody

CAT: 0384-MB67059-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0384-MB67059-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation. Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97.
CAS Number
9007-83-4
Structure Composition
Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
SNURF; E3 ubiquitin-protein ligase RNF4; RING finger protein 4; Small nuclear ring finger protein; Protein SNURF
Swiss Prot
P78317
Reactivity
Human
Immunogen
Recombinant fusion protein of human RNF4. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 35 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of RNF4 protein.
Applications Notes
Western blot analysis of RNF4 expression in LNCap (A), PC3 (B), human testis tissue (C) whole cell lysates.
Host or Source
Mouse

Related Products

CatalogName
BS74718-01RNF4 polyclonal antibody
MB12230RNF14 monoclonal antibody
BS40675-01RNF8 Rabbit monoclonal antibody
BS41465-01RNF7 Rabbit monoclonal antibody
BS40981-01RNF40 Rabbit monoclonal antibody
MB10331ATM monoclonal antibody
MB12206Prohibitin monoclonal antibody
MB11976CPS1 monoclonal antibody
MB11720TRIM21 monoclonal antibody
MB10243ELOVL5 monoclonal antibody

Alternative Products

CatalogName
bsm-51716MRNF4 Monoclonal Antibody
AMM86118-01RNF4 Mouse Monoclonal Antibody
E28PB4207RNF4 (17V1) Mouse Monoclonal Antibody
E45M20132V-2RNF4 Mouse Monoclonal Antibody [Clone 1F6]
E45M20132RNF4 Mouse Monoclonal Antibody [Clone:1F6]
E45M20133RNF4 Mouse Monoclonal Antibody [Clone:9F10]
E45M20133V-2RNF4 Mouse Monoclonal Antibody [Clone 9F10]
TA811231SRNF4 Mouse Monoclonal Antibody [Clone ID: OTI1F6]
AMM20132VCFRNF4 Mouse Monoclonal Antibody [Clone ID: LBI1F6]
AMM20133VCFRNF4 Mouse Monoclonal Antibody [Clone ID: LBI9F10]

Popular Products