VILIP-1 monoclonal antibody

• Background:

  Visinin-like Protein 1, also called VILIP-1 and VSNL1, is a calcium-sensing protein in the central nervous system. Visinin-like Protein 1 exhibits a widespread distribution with high expression in the CNS, and lower expression levels in some peripheral tissues . Visinin-like Protein 1 responds to increased intracellular calcium concentration by translocating from the cytoplasm to membranes through calcium-dependent myristoylation at its N-terminus that allows interaction with membranes . This change in localization has been proposed to facilitate the activation of compartment-specific signal transduction for the selective activation of downstream signaling cascades . In Alzheimer’s disease, Visinin-like Protein 1 expression is decreased in the brain, including a reduced number of Visinin-like Protein 1 immunoreactive neurons ; however, the presence of the protein is increased in the CSF , suggesting that it is released from neurons during insults.

• Structure Composition:

  Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

• Product Name Alternative:

  VISL1; Visinin-like protein 1; VILIP; VLP-1; Hippocalcin-like protein 3; HLP3

• Swiss Prot:

  P62760

• Reactivity:

  Human

• Immunogen:

  Recombinant fusion protein of human VILIP-1. The exact sequence is proprietary.

• Conjugation:

  Unconjugated

• Applications:

  WB

• Dilution:

  WB (1/1000 - 1/2000)

• Purity:

  This antibody is purified through a protein G column.

• Modification:

  Unmodification

• Molecular Weight:

  ~ 18 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  Recognizes endogenous levels of VILIP-1 protein.

• Applications Notes:

  Western blot analysis of VILIP-1 expression in human brain (A), human cerebellum (B) whole cell lysates.

• Host or Source:

  Mouse

• CAS Number:

  9007-83-4