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SUMO2 monoclonal antibody

CAT: 0384-MB67045-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-MB67045-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Small ubiquitin-related modifier 1, 2 and 3 (SUMO-1, -2 and -3) are members of the ubiquitin-like protein family . The covalent attachment of the SUMO-1, -2 or -3 (SUMOylation) to target proteins is analogous to ubiquitination. This post-translational modification is a reversible, multi-step process that is initiated by cleaving a precursor protein to a mature protein. Mature SUMO-1, -2 or -3 is then linked to the activating enzyme E1, conjugated to E2 and in conjunction with E3, SUMO-1, -2 or -3 is ligated to the target protein . Ubiquitin and the individual SUMO family members are all targeted to different proteins with diverse biological functions. Ubiquitin predominantly regulates degradation of its target . In contrast, SUMO-1 is conjugated to RanGAP, PML, p53 and IκB-α to regulate nuclear trafficking, formation of subnuclear structures, regulation of transcriptional activity and protein stability . SUMO-2/-3 forms poly- (SUMO) chains, is conjugated to topoisomerase II and APP, regulates chromosomal segregation and cellular responses to environmental stress, and plays a role in the progression of Alzheimer disease .
CAS Number
9007-83-4
Structure Composition
Mouse IgG2b. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
SMT3A; SMT3H2; Small ubiquitin-related modifier 2; SUMO-2; HSMT3; SMT3 homolog 2; SUMO-3; Sentrin-2; Ubiquitin-like protein SMT3A; Smt3A
Swiss Prot
P61956
Reactivity
Human, Rat
Immunogen
Recombinant fusion protein of human SUMO2. The exact sequence is proprietary.
Conjugation
Unconjugated
Related Pathways
Jak Stat : IL-6 Receptor Signaling, NF-kB Signaling
Applications
WB, IF/ICC
Dilution
WB (1/500 - 1/1000), IF/ICC (1/10 - 1/50)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 17 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of SUMO2 protein.
Applications Notes
Western blot analysis of SUMO2 expression in CEM (A), 293 (B), C6 (C) whole cell lysates.
Host or Source
Mouse

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