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ME2 monoclonal antibody

CAT: 0384-MB66936-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-MB66936-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Malic enzymes catalyze oxidative decarboxylation of malate to pyruvate. The malic enzyme family in mammalian cells includes the cytosolic malic enzyme 1 and two mitochondrial malic enzymes . ME1 and ME2 are critical for tumor cell growth and their expression is repressed by tumor suppressor p53 . Reduced expression of ME1 and ME2 reciprocally increases the levels and activation of p53, promoting p53-mediated senescence. Research studies show ME3 is essential for the survival of pancreatic ductal adenocarcinoma following genomic deletion of ME2. Deletion of ME3is lethal to ME2-null cancer cells, which has been suggested to provide a potential therapeutic opportunity using collateral lethalit.
CAS Number
9007-83-4
Structure Composition
Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
NAD-dependent malic enzyme, mitochondrial; NAD-ME; Malic enzyme 2
Swiss Prot
P23368
Reactivity
Human, Mouse
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human ME2. The exact sequence is proprietary.
Conjugation
Unconjugated
Related Pathways
Warburg Effect
Applications
WB, IHC
Dilution
WB (1/1000 - 1/2000), IHC (1/50 - 1/200)
Purity
This antibody is purified through a protein G column.
Modification
Unmodification
Molecular Weight
~ 60 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of ME2 protein.
Applications Notes
Western blot analysis of ME2 expression in HL60 (A), NIH3T3 (B), Jurkat (C) whole cell lysates.
Host or Source
Mouse

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