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ATIC monoclonal antibody

CAT: 0384-MB66535-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-MB66535-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis.Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1- (5-phospho-beta-D-ribosyl) imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) .Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction.Also catalyzes the cyclization of FAICAR to IMP.Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias.Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization.The de novo purine synthesis pathway includes 10 sequential steps, beginning with phosphoribosyl pyrophosphate and ending with inositol monophosphate (IMP), the first purin compound of the pathway.
CAS Number
9007-83-4
Structure Composition
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Product Name Alternative
PURH; Bifunctional purine biosynthesis protein PURH
Swiss Prot
P31939
Reactivity
Human, Mouse, Rat
Immunogen
Purified recombinant human ATIC protein fragments expressed in E.coli.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 58 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of ATIC protein.
Applications Notes
Western blot analysis of ATIC expression in Jurkat (A), Hela (B), U2OS (C), mouse brain (D), rat liver (E) whole cell lysates.
Host or Source
Mouse

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