Products for Research Use Only
RegisterLogin

CDK4 monoclonal antibody

CAT: 0384-MB66514-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0384-MB66514-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Cyclin-dependent kinase activity is regulated by T-loop phosphorylation (Thr172 in the case of CDK4), by the abundance of their cyclin partners, and by association with CDK inhibitors of the Cip/Kip or INK family of proteins. The inactive ternary complex of CDK4/cyclin D and p27 Kip1/Cip1 requires extracellular mitogenic stimuli for the release and degradation of p27, which affects progression through the restriction point and pRb-dependent entry into S-phase. The active complex of CDK4/cyclin D targets the retinoblastoma protein for phosphorylation, allowing the release of E2F transcription factors that activate G1/S-phase gene expression. In HeLa cells, upon UV irradiation, upregulation of p16 INK4A association with CDK4/cyclin D3 leads to a G2 delay, implicating CDK4/cyclin D3 activity in progression through the G2-phase of the cell cycle.
CAS Number
9007-83-4
Structure Composition
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Product Name Alternative
Cyclin-dependent kinase 4; Cell division protein kinase 4; PSK-J3
Swiss Prot
P11802
Reactivity
Human, Mouse, Rat
Immunogen
Purified recombinant human CDK4 protein fragments expressed in E.coli.
Conjugation
Unconjugated
Related Pathways
Immune checkpoint signaling in the Tumor Microenvironment
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 33 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of CDK4 protein.
Applications Notes
Western blot analysis of CDK4 expression in Hela (A), Lncap (B), F9 (C) whole cell lysates.
Host or Source
Mouse

Related Products

CatalogName
BS90281Cdk4 polyclonal antibody
BS6462-01CDK4 polyclonal antibody
BS90282Cdk4 polyclonal antibody
PPL00642-2aPCMV-HA-CDK4
BS80289[KO Validated] CDK4 polyclonal antibody
BS80071-01[KO Validated] CDK4 polyclonal antibody
BS74017-01Phospho-CDK4-T172 polyclonal antibody
BS45518-01CDK4 Recombinant Rabbit mAb
BS47044-01CDK4 Recombinant Rabbit mAb
BS47339CDK4 Recombinant Rabbit mAb

Alternative Products

CatalogName
MBS7135277-01CDK4 Monoclonal Antibody
NBP3-20642-100ugRabbit Monoclonal CDK4 Antibody (CDK4/7987R)
ASA-B0431CDK4 Antibody (monoclonal)
NBP3-21078PCPRabbit Monoclonal CDK4 Antibody (CDK4/7987R) [PerCP]
NBP3-21078APCRabbit Monoclonal CDK4 Antibody (CDK4/7987R) [Allophycocyanin]
NBP3-21078PERabbit Monoclonal CDK4 Antibody (CDK4/7987R) [PE]
NBP3-21078FRabbit Monoclonal CDK4 Antibody (CDK4/7987R) [FITC]
NBP3-21078BRabbit Monoclonal CDK4 Antibody (CDK4/7987R) [Biotin]
NBP3-21078HRabbit Monoclonal CDK4 Antibody (CDK4/7987R) [HRP]
GTR17765348-01Cdk4 Mouse Monoclonal Antibody

Popular Products