Products for Research Use Only
RegisterLogin

PRMT6 monoclonal antibody

CAT: 0384-MB66485-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0384-MB66485-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Protein arginine N-methyltransferase 6 (PRMT6) is a member of the protein arginine N-methyltransferase (PRMT) family of proteins that catalyze the transfer of a methyl group from S-adenosylmethionine (AdoMet) to a guanidine nitrogen of arginine . The three types of PRMTs share the ability to mono-methylate arginine residues, but vary in their ability to generate differential methylation states . Mono-methylated arginine residues are further methylated by type I PRMTs to generate an asymmetric di-methyl arginine or by type II PRMTs to form a symmetric-dimethyl arginine. Type III methyltransferases are only able to mono-methylate arginine residues . PRMT6 is a type I PRMT that acts as both a transcriptional coactivator and a corepressor and catalyzes the asymmetric di-methylation of histone H3 (Arg 2, Arg42), histone H4 (Arg3), and histone H2A at Arg29 . PRMT6 acts as a coactivator for transcription factors, including estrogen receptor and NFκB, while asymmetric di-methylation of histone H3 (Arg2) by PRMT6 prevents MLL methylation of histone H3 at Lys4 and inhibits transcription activation . In addition to its role in regulating transcription, PRMT6 methylates DNA polymerase β, leading to enhanced DNA binding and processivity during base excision repair of damaged DNA .
CAS Number
9007-83-4
Structure Composition
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Product Name Alternative
HRMT1L6; Protein arginine N-methyltransferase 6; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6; Histone-arginine N-methyltransferase PRMT6
Swiss Prot
Q96LA8
Reactivity
Human
Immunogen
Purified recombinant human PRMT6 protein fragments expressed in E.coli.
Conjugation
Unconjugated
Related Pathways
Histone Lysine Methylation Pathway
Applications
WB, IHC, IF/ICC
Dilution
WB (1/500 - 1/1000), IHC (1/50 - 1/100), IF/ICC (1/50 - 1/100)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 42 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of PRMT6 protein.
Applications Notes
Western blot analysis of PRMT6 expression in Hela (A), 293T (B) whole cell lysates.
Host or Source
Mouse

Related Products

CatalogName
BS40994-01PRMT6 Rabbit monoclonal antibody
BS78340-01PRMT6 polyclonal antibody
BS71448-01[KO Validated] PRMT6 polyclonal antibody
BS47601PRMT6 Recombinant Rabbit mAb
MB66532-01PRMT1 monoclonal antibody
MB0025PRMT1 monoclonal antibody
MB11459PRMT7 monoclonal antibody
MB11458-01PRMT3 monoclonal antibody
MB11457PRMT1 monoclonal antibody
BS9940MPRMT5 Rabbit monoclonal antibody

Alternative Products

CatalogName
GTR18047627-01PRMT6 monoclonal antibody
NBP3-07656-20ugMouse Monoclonal PRMT6 Antibody (PCRP-PRMT6-2C9)
GTR18399904-01PRMT6 Rabbit monoclonal antibody
E10G20515PRMT6 Mouse Monoclonal Antibody
AN200075PPRMT6/HRMT1L6 Monoclonal Antibody
MAB-606020427Mouse Monoclonal Antibody to PRMT6

Popular Products