MMP9 polyclonal antibody

• Background:

  The matrix metalloproteinases (MMPs) are a family of proteases that target many extracellular proteins including other proteases, growth factors, cell surface receptors, and adhesion molecules. Among the family members, MMP-2, MMP-3, MMP-7, and MMP-9 have been characterized as important factors for normal tissue remodeling during embryonic development, wound healing, tumor invasion, angiogenesis, carcinogenesis, and apoptosis. Research studies have shown that MMP activity correlates with cancer development. One mechanism of MMP regulation is transcriptional. Once synthesized, MMP exists as a latent proenzyme. Maximum MMP activity requires proteolytic cleavage to generate active MMPs by releasing the inhibitory propeptide domain from the full-length protein.

• Structure Composition:

  Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

• Product Name Alternative:

  CLG4B; Matrix metalloproteinase-9; MMP-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; GELB

• Swiss Prot:

  P14780

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein corresponding to human MMP9. The exact sequence is proprietary.

• Conjugation:

  Unconjugated

• Related Pathways:

  Tumor Angiogenesis, G Protein-coupled Receptors Signaling to MAPK Erk

• Applications:

  WB, IHC, IF/ICC

• Dilution:

  WB (1/500 - 1/1000), IHC (1/50 - 1/200), IF/ICC (1/50 - 1/200)

• Purity:

  The antibody was purified by immunogen affinity chromatography.

• Modification:

  Unmodification

• Molecular Weight:

  ~ 74 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  Recognizes endogenous levels of MMP9 protein.

• Applications Notes:

  Western blot analysis of MMP9 expression in K562 (A), Raji (B), mouse brain (C), rat kidney (D) whole cell lysates.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4