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Semaphorin 3A polyclonal antibody

CAT: 0384-BS67726-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS67726-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Semaphorins (SEMAs) comprise a family of cell surface and secreted proteins that are conserved from insects to humans. Members of this family of proteins are approximately 750 amino acids in length (including signal sequences) and are defined by a conserved extracellular “semaphorin” domain of approxi_x0002_mately 500 amino acids containing 14-16 cysteines, many blocks of conserved sequences and no obvious repeats. Secreted and cell-bound semaphorins are known to chemically attract and repel the growth of neural axons, guiding the development of intricate networks of neural tissue. In addition to their role in axonal guidance, semaphorins have also been associated with the progression of cancer. Many semaphorins bind to the receptors neuropilin and neuropilin_x0002_2, thus competing with VEGF for this interaction, which ultimately results in the suppression of angiogenesis. The loss of functional semaphorins to com_x0002_pete with VEGF may play an important role in tumor progression.
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
SEMAD; Semaphorin-3A; Semaphorin III; Sema III
Swiss Prot
O08665/Q63548
Reactivity
Mouse, Rat
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Semaphorin 3A. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 90 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of Semaphorin 3A protein.
Applications Notes
Western blot analysis of Semaphorin 3A expression in mouse brain (A) whole cell lysates.
Host or Source
Rabbit

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