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IGF2BP2 polyclonal antibody

CAT: 0384-BS67673-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS67673-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs) . This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation . Preferentially binds to N6-methyladenosine (m6A) -containing mRNAs and increases their stability . Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs . Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD .
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
IMP2; VICKZ2; Insulin-like growth factor 2 mRNA-binding protein 2; IGF2 mRNA-binding protein 2; IMP-2; Hepatocellular carcinoma autoantigen p62; IGF-II mRNA-binding protein 2; VICKZ family member 2
Swiss Prot
Q9Y6M1
Reactivity
Human
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human IGF2BP2. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB
Dilution
WB (1/500 - 1/1000)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 62 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of IGF2BP2 protein.
Applications Notes
Western blot analysis of IGF2BP2 expression in HEK293T (A), H1792 (B), K562 (C) whole cell lysates.
Host or Source
Rabbit

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