GPR146 polyclonal antibody

• Background:

  G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR146 (G protein-coupled receptor 146), also known as PGR8, is a 333 amino acid multi-pass transmembrane protein that belongs to the G-protein coupled receptor 1 family. Characterized as an orphan receptor for which its endogenous ligand has yet to be identified, GPR146 is thought to play a role in signaling events throughout the cell.

• Structure Composition:

  Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

• Product Name Alternative:

  PGR8; Probable G-protein coupled receptor 146; G-protein coupled receptor PGR8

• Swiss Prot:

  Q96CH1

• Reactivity:

  Human, Rat

• Immunogen:

  KLH-conjugated synthetic peptide encompassing a sequence within the center region of human GPR146. The exact sequence is proprietary.

• Conjugation:

  Unconjugated

• Applications:

  WB, IF/ICC

• Dilution:

  WB (1/500 - 1/1000), IF/ICC (1/50 - 1/200)

• Purity:

  The antibody was purified by immunogen affinity chromatography.

• Modification:

  Unmodification

• Molecular Weight:

  ~ 38 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  Recognizes endogenous levels of GPR146 protein.

• Applications Notes:

  Western blot analysis of GPR146 expression in A549 (A), Hela (B), rat lung (C) whole cell lysates.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4