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DLC1 polyclonal antibody

CAT: 0384-BS67466-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS67466-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Many tumor supressor genes are thought to reside on chromosome 3p because one copy of this region is frequently found to be deleted in several carcinomas. The gene encoding DLEC1 (deleted in lung and esophageal cancer protein 1), a 1,755 amino acid cytoplasmic protein, is located within a chromosomal region that is subject to abberations in many cancer cell lines and primary cancers. Reduced invasiveness and suppression of cell growth occurs when DLEC1 cDNA is introduced into a variety of cancer cell lines, suggesting that defects in the transcription of DLEC1 is a cause of lung, esophageal, and renal cancers. Evidence also suggests that methylation of the DLEC1 promoter may be associated with a poor prognosis in non-small cell lung carcinoma and nasopharyngeal carcinoma. With highest expression in kidney and prostate, there are three isoforms of DLEC1 that exist as a result of alternative splicing events.
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
DLC1; Deleted in lung and esophageal cancer protein 1; Deleted in lung cancer protein 1; DLC-1
Swiss Prot
Q9Y238
Reactivity
Human, Mouse, Rat
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human DLC1. The exact sequence is proprietary.
Conjugation
Unconjugated
Applications
WB, IHC, IF/ICC
Dilution
WB (1/500 - 1/1000), IHC (1/50 - 1/200), IF/ICC (1/50 - 1/200)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 196 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of DLC1 protein.
Applications Notes
Western blot analysis of DLC1 expression in A549 (A), Hela (B), rat oviduct (C), BV2 (D) whole cell lysates.
Host or Source
Rabbit

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