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Caspase 3 polyclonal antibody

CAT: 0384-BS67445-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS67445-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Caspase-3 (CPP-32, Apopain, Yama, SCA-1) is a critical executioner of apoptosis, as it is either partially or totally responsible for the proteolytic cleavage of many key proteins, such as the nuclear enzyme poly (ADP-ribose) polymerase (PARP) . Activation of caspase-3 requires proteolytic processing of its inactive zymogen into activated p17 and p12 fragments. Cleavage of caspase-3 requires the aspartic acid residue at the P1 position.
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1
Swiss Prot
P42574
Reactivity
Human, Mouse, Rat, Bovine, Dog, Monkey
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Caspase 3. The exact sequence is proprietary.
Conjugation
Unconjugated
Related Pathways
Regulation of Apoptosis, Death Receptor Signaling, ErbB HER Signaling, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis.
Applications
WB, IHC, IF/ICC
Dilution
WB (1/500 - 1/1000), IHC (1/50 - 1/200), IF/ICC (1/50 - 1/200)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 35 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of Caspase 3 protein.
Applications Notes
Western blot analysis of Caspase 3 expression in Raw264.7 (A), mouse brain (B), mouse lung (C), rat brain (D), rat lung (E) whole cell lysates.
Host or Source
Rabbit

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