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DARPP32 polyclonal antibody

CAT: 0384-BS67436-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS67436-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DARPP-32 (dopamine and cyclic AMP-regulated phosphoprotein, relative molecular mass 32,000) is a cytosolic protein highly enriched in medium-sized spiny neurons of the neostriatum. It is a bifunctional signaling molecule that controls serine/threonine kinase and serine/threonine phosphatase activity . Dopamine stimulates phosphorylation of DARPP-32 through D1 receptors and activation of PKA. PKA phosphorylation of DARPP-32 at Thr34 converts it into an inhibitor of protein phosphatase 1 . DARPP-32 is converted into an inhibitor of PKA when phosphorylated at Thr75 by cyclin-dependent kinase 5 (CDK5) . Mice containing a targeted deletion of the DARPP-32 gene exhibit an altered biochemical, electrophysiological, and behavioral phenotype.
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
DARPP32; Protein phosphatase 1 regulatory subunit 1B; DARPP-32; Dopamine- and cAMP-regulated neuronal phosphoprotein
Swiss Prot
Q9UD71
Reactivity
Human, Mouse, Rat, Pig
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human DARPP32. The exact sequence is proprietary.
Conjugation
Unconjugated
Related Pathways
Dopamine Signaling in Parkinson\'s Disease Plathway.
Applications
WB, IHC
Dilution
WB (1/500 - 1/1000), IHC (1/50 - 1/200)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Unmodification
Molecular Weight
~ 37 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of DARPP32 protein.
Applications Notes
Western blot analysis of DARPP32 expression in mouse heart (A), rat heart (B) whole cell lysates.
Host or Source
Rabbit

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