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CD4 (Phospho-S433) polyclonal antibody

CAT: 0384-BS67428-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS67428-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cluster of Differentiation 4 (CD4) is a glycoprotein composed of an amino-terminal extracellular domain (four domains: D1-D4 with Ig-like structures), a transmembrane part, and a short cytoplasmic tail. CD4 is expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells, and plays an important role in the development and activation of T cells. On T cells, CD4 is the co-receptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC) . Specifically, the D1 domain of CD4 interacts with the β2-domain of the MHC class II molecule. CD4 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and recruits the tyrosine kinase Lck, which is essential for T cell activation.
CAS Number
9007-83-4
Structure Composition
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Product Name Alternative
T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; CD4
Swiss Prot
P01730
Reactivity
Human, Mouse, Rat, Dog, Monkey
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CD4 with a site at pS433. The exact sequence is proprietary.
Conjugation
Unconjugated
Related Pathways
T cell receptor signaling.
Applications
WB, IF/ICC
Dilution
WB (1/500 - 1/1000), IF/ICC (1/50 - 1/200)
Purity
The antibody was purified by immunogen affinity chromatography.
Modification
Phosphorylation
Molecular Weight
~ 55 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Recognizes endogenous levels of CD4 with a site at pS433 protein.
Applications Notes
Western blot analysis of CD4 (pS433) expression in mouse spleen (A), rat spleen (B) whole cell lysates.
Host or Source
Rabbit

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