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LKB1 (Ser428) polyclonal antibody

CAT: 0384-AP0166-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-AP0166-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
LKB1 (STK11) is a serine/threonine kinase and tumor suppressor that helps control cell structure, apoptosis and energy homeostasis through regulation of numerous downstream kinases. A cytosolic protein complex comprised of LKB1, putative kinase STRAD, and the MO25 scaffold protein, activates both AMP-activated protein kinase (AMPK) and several AMPK-related kinases. AMPK plays a predominant role as the master regulator of cellular energy homeostasis, controlling downstream effectors that regulate cell growth and apoptosis in response to cellular ATP concentrations. LKB1 appears to be phosphorylated in cells at several sites, including human LKB1 at Ser31/325/428 and Thr189/336/363. Mutation in the corresponding LKB1 gene causes Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by benign GI tract polyps and dark skin lesions of the mouth, hands, and feet. A variety of other LKB1 gene mutations have been associated with the formation of sporadic cancers in several tissues.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
Serine/threonine-protein kinase STK11; Liver kinase B1; LKB1; Hlkb1; Renal carcinoma antigen NY-REN-19; STK11; LKB1, PJS
Swiss Prot
Q15831
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide, corresponding to Human LKB1.
Conjugation
Unconjugated
Related Pathways
Warburg Effect, Translational Contral elF4 and p70 S6 Kinase, Glutamine Metabolism, AMPK Signaling Pathway, MTOR signaling
Applications
WB IP
Dilution
WB: 1:1000~1:2000 IP: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 54 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
LKB1 (Ser428) polyclonal antibody detects endogenous levels of LKB1 protein.
Applications Notes
Western blot (WB) analysis of LKB1 (Ser428) polyclonal antibody at 1:2000 dilution Lane1:A549 whole cell lysate (40ug) Lane2:MCF-1 whole cell lysate (40ug) Lane3:THP-1 whole cell lysate (40ug) Lane4:K562 whole cell lysate (40ug) Lane5:PC12 whole cell lysate (40ug) Lane6:BV2 whole cell lysate (40ug)
Host or Source
Rabbit

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