Products for Research Use Only
RegisterLogin

KLHDC2 polyclonal antibody

CAT: 0384-BS79954-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0384-BS79954-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Substrate-recognition component of a Cul2-RING (CRL2 E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2 (KLHDC2 complex specifically recognizes proteins with a diglycine (Gly-Gly at the C-terminus, leading to their ubiquitination and degradation. The CRL2 (KLHDC2 complex mediates ubiquitination and degradation of truncated SELENOK and SELENOS selenoproteins produced by failed UGA/Sec decoding, which end with a diglycine. The CRL2 (KLHDC2 complex also recognizes proteolytically cleaved proteins ending with Gly-Gly, such as the N-terminal fragment of USP1, leading to their degradation. May also act as an indirect repressor of CREB3-mediated transcription by interfering with CREB3-DNA-binding.
CAS Number
9007-83-4
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
KLHDC2; HCLP-1; HCLP1; LCP
Swiss Prot
Q9Y2U9
Reactivity
Human
Immunogen
Recombinant fusion protein of human KLHDC2 (NP_055130.1) .
Conjugation
Unconjugated
Applications
WB
Dilution
WB,1:500 - 1:2000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
46kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Unmodification
Host or Source
Rabbit

Related Products

CatalogName
BS75438-01KLHDC3 polyclonal antibody
BS74476-01KLHL42 polyclonal antibody
BZ16794-01Polyclonal antibodyPN1 polyclonal antibody
MB3152-01KLHL12 (10F10) monoclonal antibody
BS75206-01AaaaaASPH polyclonal antibody
BS65563-01Mras polyclonal antibody
BS7930-01TRPM2 polyclonal antibody
BS8744-01TPH2 polyclonal antibody
BS62356-01CSP polyclonal antibody
BS90079ApoER2 polyclonal antibody

Alternative Products

CatalogName
MBS2575825-01KLHDC2 Polyclonal Antibody
TMAB-08099-01Anti-KLHDC2 Polyclonal Antibody
NBP2-14163-25ulRabbit Polyclonal KLHDC2 Antibody
GTR17706743-01KLHDC2 Rabbit Polyclonal Antibody
GTR17716645KLHDC2 Rabbit Polyclonal Antibody (HRP)
GTR17793431KLHDC2 Rabbit Polyclonal Antibody (AP)
TA334512Rabbit Polyclonal Anti-KLHDC2 Antibody
GTR17758546KLHDC2 Rabbit Polyclonal Antibody (Biotin)
70R-3738KLHDC2 antibody

Popular Products