Products for Research Use Only

NBS1/NBN polyclonal antibody

CAT: 0384-BS78190-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS78190-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
CAS Number
9007-83-4
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
NBN; AT-V1; AT-V2; ATV; NBS; NBS1; P95; nibrin
Swiss Prot
O60934
Reactivity
Human, Mouse, Rat
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human NBS1/NBN.
Conjugation
Unconjugated
Applications
WB IF/ICC IHC IP
Dilution
WB,1:500 - 1:1000|IF/ICC,1:100 - 1:500|IP,1:10 - 1:100|IHC,1:100 - 1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 95 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
NBS1/NBN polyclonal antibody detects endogenous levels of NBS1/NBN protein.
Applications Notes
Western blot analysis of Nibrin expression in HEK293T (A), A549 (B), Jurkat (C) whole cell lysates.
Host or Source
Rabbit