[KO Validated] MSH2 polyclonal antibody

• Background :

  This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC) . When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.

• Structure Composition :

  1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative :

  MSH2; COCA1; FCC1; HNPCC; HNPCC1; LCFS2; mutS homolog 2

• Swiss Prot :

  P43246

• Reactivity :

  Human, Rat

• Immunogen :

  Recombinant fusion protein of human MSH2 (NP_000242.1) .

• Conjugation :

  Unconjugated

• Applications :

  WB, IF/ICC, IP

• Dilution :

  WB,1:500 - 1:2000|IF/ICC,1:50 - 1:200|IP,1:50 - 1:200

• Purity :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification :

  Unmodification

• Molecular Weight :

  105KDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  Unmodification

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4