Bmi1 polyclonal antibody

• Background:

  This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1) . This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene.

• Structure Composition:

  1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  BMI1; FLVI2/BMI1; PCGF4; RNF51; flvi-2/bmi-1; Bmi1

• Swiss Prot:

  P35226

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide of human Bmi1 (NP_005171.4) .

• Conjugation:

  Unconjugated

• Applications:

  WB, IP

• Dilution:

  WB,1:500 - 1:2000|IP,1:50 - 1:100

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  43KDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  Unmodification

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4