Integrin beta 4 polyclonal antibody

• Background:

  Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.

• Structure Composition:

  50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

• Product Name Alternative:

  CD104

• Swiss Prot:

  A2A863

• Reactivity:

  Human

• Immunogen:

  Recombinant protein of mouse Integrin beta 4

• Conjugation:

  Unconjugated

• Applications:

  WB, IHC-P

• Dilution:

  WB: 1/500-1/1000 IHC: 1/50-1/100

• Purity:

  Affinity Purified

• Modification:

  Unmodified

• Molecular Weight:

  Calculated MW: 202 kDa; Observed MW: 202 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  IgG

• Applications Notes:

  Western blot analysis of Integrin beta 4 in SW480 lysates using Integrin beta 4 antibody.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4