SNAP25 polyclonal antibody

• Background :

  SNAP25 forms a core complex with the SNARE proteins syntaxin and synaptobrevin to mediate synaptic vesicle fusion with the plasma membrane during Ca2+-dependent exocytosis. This complex is responsible for exocytosis of the neurotransmitter γ-aminobutyric acid (GABA) . Neurotransmitter release is inhibited by proteolysis of SNAP25 by botulinum toxins A and E. SNAP25 plays a secondary role as a Q-SNARE involved in endosome fusion; the protein is associated with genetic susceptibility to attention-deficit hyperactivity disorder (ADHD) .

• Structure Composition :

  Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Product Name Alternative :

  Synaptosomal-associated protein 25; SNAP-25; Super protein; SUP; Synaptosomal-associated 25 kDa protein; SNAP25; SNAP

• Swiss Prot :

  P60880

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  A synthesized peptide derived from human SNAP25

• Conjugation :

  Unconjugated

• Applications :

  WB, ICC/IF, IP

• Dilution :

  WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20

• Purity :

  Affinity Purified

• Modification :

  Unmodified

• Molecular Weight :

  Calculated MW: 23 kDa; Observed MW: 23 kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  IgG

• Applications Notes :

  Western blot analysis of SNAP25 in SH-SY5Y lysates using SNAP25 antibody.

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4