ERCC1 polyclonal antibody

• Background:

  DNA repair systems operate in all living cells to manage a variety of DNA lesions. Nucleotide excision repair (NER) is implemented in cases where bulky helix-distorting lesions occur, such as those brought about by UV and certain chemicals. Research studies have shown that expression of ERCC1 is related to survival rate and response to chemotherapeutic drugs in several human cancers including non-small cell lung cancer (NSCLC) .

• Structure Composition:

  Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Product Name Alternative:

  ERCC1; DNA excision repair protein ERCC-1

• Swiss Prot:

  P07992

• Reactivity:

  Human, Mouse

• Immunogen:

  A synthesized peptide derived from human ERCC1

• Conjugation:

  Unconjugated

• Applications:

  WB, IHC-P, ICC/IF

• Dilution:

  WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200

• Purity:

  Affinity Purified

• Modification:

  Unmodified

• Molecular Weight:

  Calculated MW: 33 kDa; Observed MW: 36 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  IgG

• Applications Notes:

  Western blot analysis of ERCC1 in HeLa lysates using ERCC1 antibody.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4