KMT6 polyclonal antibody

• Background :

  Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.

• Structure Composition :

  Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Product Name Alternative :

  WVS; ENX1; KMT6; WVS2; ENX-1; EZH2b; KMT6A; EZH2

• Swiss Prot :

  Q15910

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  A synthesized peptide derived from human KMT6 / EZH2

• Conjugation :

  Unconjugated

• Applications :

  WB, IHC-P, ICC/IF, FC

• Dilution :

  WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 FC: 1/50-1/100

• Purity :

  Affinity Purified

• Modification :

  Unmodified

• Molecular Weight :

  Calculated MW: 85 kDa; Observed MW: 98 kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  IgG

• Applications Notes :

  Western blot analysis of KMT6 / EZH2 in HEK293 lysates using KMT6 antibody.

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4