HDAC8 polyclonal antibody

• Background:

  Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility.

• Structure Composition:

  Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Product Name Alternative:

  HDAC8; HDACL1; CDA07; Histone deacetylase 8; HD8

• Swiss Prot:

  Q9BY41

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthesized peptide derived from human HDAC8

• Conjugation:

  Unconjugated

• Applications:

  WB, IP, FC

• Dilution:

  WB: 1/500-1/1000 IP: 1/20 FC: 1/50-1/100

• Purity:

  Affinity Purified

• Modification:

  Unmodified

• Molecular Weight:

  Calculated MW: 42 kDa; Observed MW: 42 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  IgG

• Applications Notes:

  Western blot analysis of HDAC8 in HeLa lysates using HDAC8 antibody.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4