Phospho-alpha Synuclein (Ser129) polyclonal antibody

• Background:

  May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. Genetic alterations of SNCA resulting in aberrant polymerization into fibrils, are associated with several neurodegenerative diseases (synucleinopathies) .

• Structure Composition:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

• Product Name Alternative:

  SNCA; NACP; PARK1; Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP

• Swiss Prot:

  P37840

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic peptide of human SNCA

• Conjugation:

  Unconjugated

• Applications:

  WB, IHC-P

• Dilution:

  WB: 1/500-1/1000 IHC: 1/50-1/100

• Purity:

  Affinity Purified

• Modification:

  Phosphorylated

• Molecular Weight:

  Calculated MW: 14 kDa; Observed MW: 18 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  IgG

• Applications Notes:

  Western blot analysis of Phospho-alpha Synuclein in mouse brain lysates using Phospho-alpha Synuclein antibody.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4