STRADA polyclonal antibody

• Background:

  The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25) . The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  LYK5; PMSE; Stlk; STRAD; NY-BR-96

• Swiss Prot:

  Q7RTN6

• Reactivity:

  Human

• Immunogen:

  Synthetic peptide, corresponding to Human STRADA.

• Conjugation:

  Unconjugated

• Applications:

  WB ICC/IF FC

• Dilution:

  WB: 1:500~1:1000 ICC/IF: 1:50~1:100 FC: 1:10~1:30

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodified

• Molecular Weight:

  ~ 48 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  STRADA polyclonal antibody detects endogenous levels of STRADA protein.

• Applications Notes:

  Western blot analysis of STRAD alpha expression in Jurkat (A) whole cell lysates.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4