LSD2 / AOF1 Rabbit monoclonal antibody

• Background:

  Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

• Product Name Alternative:

  AOF1; KDM1B; LSD2; Lysine-specific histone demethylase 1B; Lysine-specific histone demethylase 2

• Swiss Prot:

  Q8NB78

• Reactivity:

  Human Mouse Rat

• Immunogen:

  A synthesized peptide derived from human LSD2 / AOF1

• Conjugation:

  Unconjugated

• Applications:

  WB ICC/IF IP FC

• Dilution:

  WB 1:500~1:2000 ICC/IF 1:50~1:200 IP 1:60 FC 1:50

• Purity:

  Affinity-chromatography

• Modification:

  Unmodified

• Molecular Weight:

  92kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  LSD2 / AOF1 Antibody detects endogenous levels of total LSD2 / AOF1

• Applications Notes:

  Western blot analysis of LSD2 / AOF1 expression in (1) HeLa cell lysate; (2) RAW264.7 cell lysate; (3) PC12 cell lysate.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4