M6PR Rabbit monoclonal antibody

• Background:

  Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

• Product Name Alternative:

  IGF2R; CI Man-6-P receptor; CI-MPR; M6PR; MPR 300; Insulin-like growth factor 2 receptor; M6P/IGF2R; CD222

• Swiss Prot:

  P11717

• Reactivity:

  Human Mouse Rat

• Immunogen:

  A synthesized peptide derived from human M6PR

• Conjugation:

  Unconjugated

• Applications:

  WB IHC ICC/IF IP FC

• Dilution:

  WB 1:5000~1:20000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:30 FC 1:100

• Purity:

  Affinity-chromatography

• Modification:

  Unmodified

• Molecular Weight:

  274kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  M6PR Antibody detects endogenous levels of total M6PR

• Applications Notes:

  Western blot analysis of extracts of M6PR expression in Jurkat cell lysate.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4