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FOSL2 polyclonal antibody

CAT: 0384-BS7119-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS7119-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The v-Fos oncogene was initially identified as the transforming gene of two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phosphoprotein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA TPA response elements (TREs), c-Fos proteins are only active as heterodimers with members of the Jun gene family. Murine Fos B encodes a nuclear protein of 338 amino acids which has 70% homology with c-Fos, exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B, which bind to TRE DNA response elements. Functional homologs of c-Fos and Fos B include Fra-1 and Fra-2 genes.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Fos-related antigen 2; FRA-2; FOSL2; FRA2
Swiss Prot
P15408
Reactivity
Human, Mouse, Rat
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human FOSL2.
Conjugation
Unconjugated
Applications
WB IHC IF/ICC
Dilution
WB 1:500 - 1:1000 IHC 1:50 - 1:100 IF/ICC 1:50 - 1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 31-35 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
FOSL2 polyclonal antibody detects endogenous levels of FOSL2 protein.
Applications Notes
Western blot analysis of FOSL2 expression in HEK293T (A), Hela (B), H446 (C), mouse liver (D), mouse kidney (E), rat liver (F), rat kidney (G) whole cell lysates.
Host or Source
Rabbit

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