CD22 polyclonal antibody

CAT: 0384-NCP0191P-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-NCP0191P-01Size:50 µL
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Background
CD22 (also known as siglec-2) is a member of the sialic acid-binding immunoglobulin-type lectin (Siglec) family of immunomodulatory receptors. CD22 can bind to its ligand α 2,6-linked sialic acid on different cells (trans interaction) as well as on the same cells (cis interaction) . CD22 is predominantly expressed on B cells and functions as an inhibitory co-receptor for the B cell receptor (BCR) . After BCR ligation, the tyrosine kinase Lyn is activated and phosphorylates two distal of the four ITIM motifs in the intracellular carboxy-terminal region of CD22, which then recruit tyrosine phosphatases, including SHP-1, to the plasma membrane, and in turn, they get tyrosine-phosphorylated and activated to damp the signaling pathways initiated by BCR ligation. CD22 has been actively pursued as a therapeutic target for autoimmune diseases. Due to almost exclusive expression on B cells, it is also actively pursued as a therapeutic target for multiple B cell malignancies.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; CD22; SIGLEC2
Swiss Prot
P20273
Reactivity
Human
Immunogen
Recombinant protein of human CD22.
Conjugation
Unconjugated
Applications
WB IF
Dilution
WB: 1:2000~1:5000 IF 1:100 - 1:500
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 120 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CD22 polyclonal antibody detects endogenous levels of CD22 protein.
Applications Notes
Western blot (WB) analysis of CD22 polyclonal antibody at 1:2000 dilution Lane1:Myla2059 whole cell lysate (30ug) Lane2:HuT78 whole cell lysate (30ug)
Host or Source
Rabbit

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