CD113/NECTIN3 polyclonal antibody

• Background :

  Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.

• Structure Composition :

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

• Product Name Alternative :

  Nectin-3; CDw113; Nectin cell adhesion molecule 3; Poliovirus receptor-related protein 3; CD113; NECTIN3 ; PRR3; PVRL3

• Swiss Prot :

  Q9NQS3

• Reactivity :

  Human, Rat, Mouse

• Immunogen :

  Recombinant protein of human CD113/NECTIN3.

• Conjugation :

  Unconjugated

• Applications :

  IF

• Dilution :

  IF: 1:100~1:500

• Purity :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification :

  Unmodified

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  CD113/NECTIN3 polyclonal antibody detects endogenous levels of CD113/NECTIN3 protein.

• Applications Notes :

  Immunofluorescence analysis of MCF-7 cells using CD113/NECTIN3 pAb at dilution of 1:200 (40x lens) .

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4