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GYS1 polyclonal antibody

CAT: 0384-BS61282-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS61282-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Glycogen [starch] synthase belongs to the mammalian/fungal glycogen synthase family of proteins. Two forms of this protein exist, a liver form and a muscle form, both of which have the same function in the glycogen biosynthesis pathway. Glycogen synthase transfers the glycosyl residue from UDP-Glucose to the nonreducing end of å-1,4-glucan. The liver glycogen synthase protein is truncated by 34 amino acids compared to the muscle form. However, these enzymes differ significantly in their amino- and carboxyl-terminal regions. Muscle glycogen synthase serves to fuel muscular activity only and is regulated by muscle contraction and by catecholamines. Liver glycogen synthase mediates blood glucose homeostasis in response to nutritional cues. Defects in the gene encoding liver glycogen synthase results in glycogen storage disease type 0 (GSD0), a rare form of fasting ketotic hypoglycemia.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Glycogen [starch] synthase, muscle (EC:2.4.1.11) ; GYS1; GYS
Swiss Prot
P13807
Reactivity
Human, Mouse, Rat
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human GYS1.
Conjugation
Unconjugated
Related Pathways
Regulation of Actin Dynamics, Insulin &Glucose Signaling
Applications
WB IHC
Dilution
WB 1:500 - 1:1000 IHC 1:50 - 1:100
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 95 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
GYS1 polyclonal antibody detects endogenous levels of GYS1 protein.
Applications Notes
Western blot analysis of GYS1 expression in HEK293T (A), LO2 (B), HepG2 (C), AML12 (D), H9C2 (E) whole cell lysates.
Host or Source
Rabbit

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