TGFβ RII (E246) polyclonal antibody

CAT: 0384-AP0461-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-AP0461-01Size:50 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Transforming growth factor-β (TGF-β) superfamily members are critical regulators of cell proliferation and differentiation, developmental patterning and morphogenesis, and disease pathogenesis. TGF-β elicits signaling through three cell surface receptors: type I (RI), type II (RII), and type III (RIII) . Type I and type II receptors are serine/threonine kinases that form a heteromeric complex. In response to ligand binding, the type II receptors form a stable complex with the type I receptors allowing phosphorylation and activation of type I receptor kinases. The type III receptor, also known as betaglycan, is a transmembrane proteoglycan with a large extracellular domain that binds TGF-β with high affinity but lacks a cytoplasmic signaling domain. Expression of the type III receptor can regulate TGF-β signaling through presentation of the ligand to the signaling complex. The only known direct TGF-β signaling effectors are the Smad family proteins, which transduce signals from the cell surface directly to the nucleus to regulate target gene transcription.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
TGF-beta receptor type-2; TGFR-2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II
Swiss Prot
P37173
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide, corresponding to Human TGFβ RII.
Conjugation
Unconjugated
Related Pathways
Contribution of Soluble Factors to EMT
Applications
WB IP
Dilution
WB: 1:1000~1:2000 IP: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 65 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
TGFβ RII (E246) polyclonal antibody detects endogenous levels of TGFβ RII protein.
Applications Notes
Western blot (WB) analysis of TGFβ RII (Ser428) polyclonal antibody at 1:1000 dilution Lane1:BV2 whole cell lysate (40ug) Lane2:PC12 whole cell lysate (50ug) Lane3:PC3 whole cell lysate (60ug) Lane4:HEPG2 whole cell lysate (50ug) Lane5:A549 whole cell lysate (60ug)
Host or Source
Rabbit

Related Products

CatalogName
BS1360-01TGFβ RII (I122) polyclonal antibody
BS91337TGFα polyclonal antibody
BS60009-01TGFα polyclonal antibody
BZ16799PKA RII beta polyclonal antibody
BS2616-01CRF-RII (H112) polyclonal antibody
BZ16928TGF alpha polyclonal antibody
BS1359-01TGFα (R139) polyclonal antibody
BZ16459TGF beta 1 polyclonal antibody
BS1363-01TGF β3 (G292) polyclonal antibody
BS1361-01TGFβ1 (Y369) polyclonal antibody

Alternative Products

CatalogName
E43P0461TGFβ RII (E246) polyclonal antibody
E20-75702TGFα Polyclonal Antibody
RA20173-01TGFβ1 Rabbit Polyclonal Antibody(TGF)
MBS8532673-01TGF beta1 Polyclonal Antibody
APR10403GPolyclonal TGF-beta2 Antibody
RA20514-01TGFβ2 Polyclonal Antibody
UB-GEN-15390TGFβ3 Polyclonal Antibody
UB-GEN-15389TGFβ1 Polyclonal Antibody
RA30436-01TGFβ RIII Polyclonal Antibody
BT-AP14903-01TGF alpha Polyclonal Antibody

Popular Products