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PINK1 polyclonal antibody

CAT: 0384-BS79658-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS79658-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PTEN induced putative kinase 1, PINK1, is a mitochondrial serine/threonine kinase involved in the normal function and integrity of mitochondria, as well as in reduction of cytochrome c release from mitochondria. PINK1 phosphorylates Parkin and promotes its translocation to mitochondria. Research studies have shown that mutations in PINK1 are linked to autosomal recessive early onset Parkinson’s disease, and are associated with loss of protective function, mitochondrial dysfunction, aggregation of α-synuclein, as well as proteasome dysfunction.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Serine/threonine-protein kinase PINK1 mitochondrial; BRPK; PTEN-induced putative kinase protein 1
Swiss Prot
Q9BXM7
Reactivity
Human, Mouse, Rat
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human PINK1.
Conjugation
Unconjugated
Applications
WB IHC IF
Dilution
WB 1:500 - 1:1000 IHC 1:50 - 1:100 IF 1:50 - 1:100
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 60 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
PINK1 polyclonal antibody detects endogenous levels of PINK1 protein.
Applications Notes
Western blot analysis of PINK1 expression in HEK293T (A), MCF7 (B), HCT116 (C), mouse heart (D), rat testis (E) whole cell lysates.
Host or Source
Rabbit

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