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FMO1 Polyclonal Antibody

CAT: 0384-BS8574-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS8574-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
FMO1; flavin containing monooxygenase 1
Swiss Prot
Q01740
Reactivity
Human, Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 371-470 of human FMO1 (NP_002012.1) .
Conjugation
Unconjugated
Applications
WB IF/ICC
Dilution
WB: 1:500-1:1000 IF/ICC: 1:50-1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 60 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
FMO1 Polyclonal Antibody detects endogenous levels of FMO1 protein.
Applications Notes
Western blot analysis of lysates from Rat liver using FMO pAb at 1:1000 dilution.
Host or Source
Rabbit

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